Research from the 2010 Annual European Society of Human Reproduction and Embryology (ESHRE).
The researchers reviewed previously published studies and determined that early pregnancy complications increase the risk that the pregnancy will have complications and future pregnancies are at higher risk also.
I was personally impressed with the data because I had not appreciated the extent of these finding. I think these studies demonstrate to physicians that we need larger trials to bring us the information that we sometimes cannot gain through our own individual experience.
This information is not commonly appreciated and suggests that we should warn follow these pregnancies very carefully and take every precaution to prevent early labor
Dr Robbert van Oppenraaij told the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam today (Monday) that he and his colleagues from the UK, Denmark and Spain had reviewed 75 studies carried out between 1980-2008 that looked at the impact of early pregnancy complications.
“There were several interesting findings:
- Firstly, we found that after any first trimester complication or event, the risk of preterm or very preterm delivery is increased in the subsequent or ongoing pregnancy;
- Secondly, we found that increased risks of adverse obstetric outcome are, in all cases, related to the severity or recurrence, or both, of the first trimester complication or event.
- To our knowledge, this is the first comprehensive review in which the impact of more than one first trimester complication on adverse obstetric outcome has been investigated systematically.”
For instance, vaginal bleeding in the first trimester increased the risk of
- premature or very premature delivery and
- more than doubled the risk of low birth weight and very low birth weight.
- These risks were further increased after detection of an intrauterine haematoma.
The survivor in a vanishing twin pregnancy (a twin pregnancy in which one twin miscarries very early in the pregnancy) was at increased risk of
- premature or very premature delivery,
- had double the risk of low birth weight,
- three times the risk of very low birth weight, and
- more than three times the risk of perinatal death.
Extreme early morning sickness (hyperemesis gravidarum) was associated with
- a three-fold increased risk of premature delivery and
- a nearly three-fold risk of low birth weight.