I have come to believe that one of the key factors that differentiates IVF outcomes is individualization and management of ovarian stimulation. My work with Klaus Wiemer, PhD taught me that our choice of cycle preparation (OCP or no OCP and length of OCP) plus cycle type (antagonist versus long-lupron versus micro-dose lupron), plus medication dose all contributed to the overall goal of the stimulation of providing the best egg quality to the lab so that they could deliver high-quality embryos.
This review article adresses this concept that we need to look at a variety of clinical tests to help us individualize ovarian stimulation. I will not go so far as to say that every patient needs a unique protocol, there are only so many variable anyway. Still, this is an important concept.
Take Home Message
- Clinical tests help us individualize ovarian stimulation protocols
- Stimulation protocols may require modification based on the patient profile
- The goal of individualization is to deliver the eggs in the best quality to the lab so they can produce the best embryos
Conventional ovarian stimulation no longer exists: welcome to the age of individualized ovarian stimulation
by Luciano G. Nardo, Richard Fleming, Colin M. Howles, Ernesto Bosch, Samir Hamamah, Filippo M. Ubaldi, Jean-Noel Hugues, Adam H. Balen, Scott M. Nelson
Reproductive BioMedicine Online (Vol.23, Issue 2)