This review article summarizes the current data. Unfortunately, most studies did not control for the confounding variables that might affect outcomes besides paternal age.
The article references a good study that did correct for confounding variables and did find that paternal age decreases success rates. We need additional good studies to make a decision.
Remember, fertility is a “team sport” and both partners are critical determinants of success.
The effect of paternal age on assisted reproduction outcome
To summarize the current knowledge about the association between paternal age and assisted reproductive technology (ART) outcomes because most studies examine the effect of maternal age on ART outcomes.
Systematic review of the literature
- The 10 studies included in this review did not show a clear correlation between advanced paternal age and rates of fertilization, implantation, pregnancy, miscarriage, and live birth.
- Paternal age was not found to affect embryo quality at the cleavage stage (days 2–3).
- However, a significant decrease in blastocyst embryo formation was associated with increased paternal age, probably reflecting male genomic activation within the embryo.
- Except for volume, characteristics of semen such as motility, concentration, and morphology did not decrease with age.
There is insufficient evidence to demonstrate an unfavorable effect of paternal age on ART outcomes. Further study with well-defined entry criteria and uniform reporting of outcomes is needed to investigate the subject.
[button link=”http://1.usa.gov/dEPTmL”]Abstract Link[/button] [button link=”http://1.usa.gov/fUs3nz” color=”green”]Second Reference[/button]