The CCT (Clomid Challenge Test) is a test to determine the presence of diminished egg quality. ALL women will eventually loose their fertility (menopause). Sometimes, infertility represents the premature onset of menopause.
The CCT should be thought of as a stress test of the reproductive hormone system. Endocrinologists use stress tests to diagnose diabetes, thyroid disease and other endocrine system disorders.
We schedule an appointment on Cycle Day 2-4 depending on the clinic and the patient’s schedule. During the appointment, we draw a blood sample for hormones (FSH, LH, Estradiol, AMH – Anti-Mullerian Hormone) and then we perform a vaginal ultrasound of the pelvic organs but we are most interested in the ovaries. We measure the size of the ovaries (volume) and count the number of antral follicles (AFC – Antral Follicle Count).
The woman then takes a fertility drug, Clomid (Clomiphene Citrate) 100 mg, for 5 days and then returns for a blood level of FSH on Cycle Day 10.
If the blood level of FSH is elevated then the egg quality is reduced. The higher the level of FSH the lower the egg quality. For any value of FSH, the older the woman the lower the fertility potential.