Researchers found that day 3 embryos biopsied for PGD implanted at the same rate as embryos from non-PGD cycles. Compared to routine IVF, their blastocyst survival rate after thawing = 87% versus 88% respectively. The implantation and clinical pregnancy rates were 35% versus 29% and 34% versus 36% respectively). The overall ongoing pregnancy rate for … Read More »
The study showed that the size of the embryo cohort does not affect the rate of normal embryos identified by PGD. The authors used array CGH to evaluate embryos on day 3 and day 5. The study was retrospective using data from a PGD reference lab. They studied 7753 embryos from 990 patients. Embryo Cohort Findings … Read More »
Metformin reduces risk of OHSS in patients with PCO during gonadotropin-stimulated IVF cycles – a randomized controlled trial. (Article in-press at Fertility and Sterility Journal) [box type=”info”]Take Home Message [unordered_list style=”green-dot”] Metformin reduced the relative risk of OHSS to 28% (range = 11% – 67%) of that without metformin supplements The study had a very … Read More »
I have come to believe that one of the key factors that differentiates IVF outcomes is individualization and management of ovarian stimulation.
Japanese researchers explored a national database to determine whether thawed single-blast embryo transfer in natural cycles would reduce the risk of an ectopic pregnancy.
A prospective study demonstrates that frozen vitrified donor eggs yield the same outcome as fresh donor eggs in this nice prospective study. Egg freezing has been long in the development because the egg (oocyte) is particularly sensitive to the freezing-thawing process.
Take Home Message on Embryo Quality and Frozen Transfer Cycles: Embryo quality (measured as morphology or shape) remains an important factor for selecting which embryo to transfer. Some clinics do not keep embryo quality information on their frozen embryos. Thus, they randomly transfer embryos in the frozen cycle and their success rates are not optimized … Read More »
[box type=”info”] This review article summarizes the current data. Unfortunately, most studies did not control for the confounding variables that might affect outcomes besides paternal age. The article references a good study that did correct for confounding variables and did find that paternal age decreases success rates. We need additional good studies to make a … Read More »
Deep phenotyping to predict live birth outcomes in IVF – the authors suggest that their mathematical model is 100x more accurate than using age to predict IVF outcomes. The authors took data from previous IVF cycles at Stanford and developed a model using complicated statistical tests. They tested the model on IVF cycles from a … Read More »
Genetic technologies invade every aspect of medicine. Here we find another example of a technology that could significantly assist us in identifying the embryo that will make a baby. The authors suggest measuring telomere length may be a measure of embryo health. If so, then this test may be a very valuable tool to access … Read More »